Physical and chemical factors leading to the development of environment – related immunosuppressive syndrome and the rehabilitation

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The Monography formate bаsiс knowledge about toxicology effect by lead.
Lead toxicity is an important environmental disease and its effects on the human
body are devastating. There is almost no function in the human body which is
not affected by lead toxicity. Though in countries like US and Canada the use
of lead has been controlled up to a certain extent, it is still used vehemently in
the developing countries. This is primarily because lead bears unique physical
and chemical properties that make it suitable for a large number of applications
for which humans have exploited its benefits from historical times and thus it
has become a common environmental pollutant. Lead is highly persistent in the
environment and because of its continuous use its levels rise in almost every
country, posing serious threats. This article reviews the works listed in the
literature with recent updates regarding the toxicity of lead. Focus is also on
toxic effects of lead on the renal, reproductive and nervous system. Finally the
techniques available for treating lead toxicity are presented with some recent
updates.

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Product Description

CONTENT
DEFINITIONS …………………………………..5
SYMBOLS AND ABBREVIATIONS
INTRODUCTION………………………………8
BASIC PART
CHAPTER 1. Physiology of the immune system and
ecology…………………………………………….17
1.1 Factors contributing to the development of
environmentally conditioned secondary
immunodeficiency states……………………22
CHAPTER 2. Lead. Basic physical and chemical
properties………………………………………….25
2.1 Industrial use of lead ………………….25
2.2 Lead pollution of the environment…….. 28
2.2.1 Lead sources of intoxication in Kazakhstan…29
2.2.2 Hygienic regulation of lead content in water
and soil……………………………………………….41
2.3 Ways of lead intake, distribution and
excretion from the body…………………………46
2.3.1 Industrial and domestic lead poisoning 53
CHAPTER 3. Physiological mechanism of action of lead
compounds. Clinic of acute and chronic lead
intoxication……………………………………………61
3.1 Cytological and biochemical analysis of the
effects of lead compounds on animals and
humans………………………………………….84
3.2 Immune system and lead intoxication…90
3.2.1 The Influence of salts of zinc, lead,
cadmium on leukogram of blood…………..93
3.2.2 Daily dynamics of blood leukogram in
normal, acute and chronic intoxication of
rats with lead, zinc, cadmium and combined
poisoning……………………………………………..103
4
3.2.3 The influence of salts of zinc, lead and
cadmium on the myelogram of the bone
marrow……………………………………………110
CHAPTER 4. Measures aimed at leveling intoxication
processes from lead compounds…………….113
4.1 Тhe Range of immunostimulatory drugs
used in clinical practice…………………………..119
4.2 New Synthesized Immunostimulants,
effective in lead intoxication……………………..126
4.2.1 Acute toxicity of new compounds……..133
4.2.2 Immunostimulating activity of new
compounds…………………………………………….136
4.3 Effect of the new immunostimulating
compounds on the functional state of the
cardio-respiratory system……………………….153
4.3.1 Effect of the new immunostimulating
compounds on the functional state of the
respiratory system in the acute and chronic
intoxication……………………………………………….153
4.3.2 Effect of the new immunostimulating
compounds on the functional state of the
cardiovascular system in acute and chronic
intoxication…………………………………………….156
CONCLUSION ………….162
REFERENCE ……………..175

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